Date: Jul.2000 |
(1) An artificial Cu(II) complex with intringuing oxygen radicalquenching
profile. X-ray structure, cytochrome c assay, and ESR study.
Msami Otsuka, Honoo Satake, Satoru Murakami, Mitsunobu Doi, Toshimasa Ishida, Masakatsu Shibasaki and Yukio Sugiura. (1996). Bioorg. Med. Chem. 4, 1703-1708. Since reactive oxygen species (ROS) play critical roles invarious biological processes, such as defense of human biochemical system or signal transduction pathways associated with immune responce and growth control, development of oxygen activators or scavengers of oxygen radical is of increasing importance. Recently, we have reported that novel ligand, constructed from pyridine and histidine units, namely HPH, showed potent activity to active molecular oxygen, as demonstrated by ESR spin trapping. Herein we reported our finding that replacement of the secondary amino linkage of HPH by a peptide bond, as envisaged in HPH-Pep switches the oxygen-activating capability to the reverse activity to scavenge oxygen radical. In addtion, enzyyme assay and ESR studies indicated that the Cu(II) complex of the new ligand HPH-Pep has an intriguing radical-scavenged superoxide specifically wothout and hydroxyl radical, and HPH-Pep-Cu(II) did not generate hydorgen peroxide upon scavenging superoxide. (2) Synthesis, Characterization, and spectroscopic properties of three novel pentadentate copper(II) complex related to the metal-chelating inhibitors against DNS binding with HIV-EP1. Kurosaki, H.; Sharma, R.K.; Aoki, S.; Inoue, T.; Okamoto, Y.; Sugiura, Y.; Doi, M.; Ishida, D.; Otsuka, M.; Goto, M. (2001) J. Chem. Soc., Dalton Trans. 441-447. |
This structer was produced by Swiss-PdbViewer.
X-Ray Data Summary
| formula | C23 H21 Cu N6 O5, 2(H2 O) | ||
| weight | 561.03 | ||
| symmetry | tetragonal | ||
| space group | P43212 | ||
| Cell | Crystal | ||
| a | 16.854(5) Ang. | description | block |
| b | 16.854(5) Ang. | colour | green |
| c | 19.824(9) Ang. | size (mm) | 0.5x0.3x0.3 |
| alpha | 90 deg. | Dx (g/ml) | 1.324 |
| beta | 90 deg. | F(000) | 2320 |
| gamma | 90 deg. | mu(CuKa) | 1.523 |
| volume | 5631(3) Ang^3 | ||
| Z | 8 | ||
| Diffrn measurement | Refinementspace | ||
| device type | Rigaku AFC5R/RU-200 | Flack | -0.16(9) |
| decay | 1.0 % | parameters | 335 |
| index limit | 0-h-19, 0-k-13, -22-L-0 | restraints | 0 |
| theta (deg.) | 3.44-62.22 | R_factor_gt | 0.0791 |
| total reflections | 2548 | wR_factor_gt | 0.2103 |
| reflections(obs) | 2375 .gt. 2sigma(I) | dela rho_max | 1.173 e A^3 |
| Structure | space space space space space space | delta rho_min | -0.407 e A^3 |
| solution | SHELXS-97 | shift/su_max | lt.0.001 |
| refinement | SHELXL-97 | Goodness of fit | 1.092 |
Get PDB coordinates
Back to the structure index
