Dankasterone, produced by a strain og Gymnascella dankaliensis from the marine sponge Halichondria japonica, is a novel class of steroid with significant cytotoxicity against tumour cells in culture.

Date: Oct.1999

This structer was produced by RasMol.

ORTEP-III (Burnett, 1996) drawing

Paper: Dankasterone, a new class of cytotoxic steroid produced by a Gymnascella species from a marine sponge
Taro Amagata, Mitsunobu Doi, Makiko Tohgo, Katsuhiro Minoura & Atsushi Numata
J.Chem.Soc., Chem. Commun., 1321-1322 (1999)

X-Ray Data Summary
formulaC28 H40 O3
weight 424.6
space groupP212121
Cell Crystal
a 12.667(3) Ang. description plate
b 23.829(5) Ang. colour Colorless
c 8.134(4) Ang. size (mm) 0.6x0.3x0.05
alpha 90 deg. Dx (g/ml) 1.149
beta 90 deg. F(000) 928
gamma 90 deg. mu(CuKa) 0.563
volume 2455.4(14) Ang^3
Z 4
Diffrn measurementRefinementspace
device type Rigaku AFC5R/RU-200 Flack 0.0(6)
decay -2.0 % parameters 286
index limit -5-h-15, -9-k-29, 0-L-9 restraints 0
theta (deg.) 3.71-70.14 R_factor_gt 0.0625
total reflections3915 wR_factor_gt 0.1504
reflections(obs) 3467 .gt. 2sigma(I) dela rho_max 0.411 e A^3
Structurespace space space space space space delta rho_min -0.383 e A^3
solution SHELXS-97 shift/su_maxlt.0.001
refinementSHELXL-97 Goodness of fit 1.036

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